Rodents of Unusual Sizes can be cleared by using Bug Repellents. Tap on Rodent of Unusual Size on your playspace. Tap on your Bug Repellents and aim the green circle around a Rodent of Unusual Size. While the Rodent of Unusual Size is in the green circle, tap the checkmark to clear them.

Clearing Rodent of Unusual Size has a chance to drop the following items:
- Rope
- Virus