Pills are used to unlock Event Buildings at Qweedhog Sign and can be obtained in the following ways:

- Making Consuela Fan Herself

- Making Human Rupert Suntan

- Making Carter Upgrade Air Conditioning Unit

- Making Stewie Search for Water

- Making Jerome Give Out Ice Cream

- Making Mort Sell Portable Fans

- Making Quagmire Streak In His Underwear

- Making Cleveland Ride a Scooter

- Making Jerome Chill Out

- Making Mayor West Wipe His Sweat

- Making Connie Wear Skimpy Clothing

- Making Lois Rock the Tank Top

- Making Rockstar Peter Sweat in Spandex

- Making Working Squirrel Find Some Shade

- Making Traveling Pancake Take a Break

- Making Traveling Pancake Show His Passport

- Drop from Drag Racers

- From Pill Shrines