Wrenches are used to unlock Characters, Skins, or Buildings and can be obtained in the following ways:

- Making Quagmire Hit on Biker Ladies

- Making Joe Rig a Motor to His Wheelchair

- Making Mort Try on a Leather Jacket

- Making Seamus Tell Pirate Stories to Bikers

- Making Undead Racer Bertram Scowl at Stewie

- Clearing Motorcycle Mutants