Characters and Skins used during the Murder at the Griffin House Event include the following:
Week 1
- Mort
- Bonnie
- Chris
- Meg
- Connie
- Lois
- Joe
- Bruce
- Herbert
- Rich Widow Lois
- Detective Cleveland
- Victim Peter

Week 2
- Brian
- Bonnie
- Seamus
- Lois
- Tricia
- Chris
- Forensic Doctor Hartman
- Police Dog Brian
- Biker Stewie

Week 3
- Stewie
- Lois
- Quagmire
- Carter
- Joe
- Jerome
- Natural Monkey
- Bard Quagmire
- Roller Skater Consuela
- Eccentric Millionaire Quagmire
- True Crime Fan Meg
- Anime Fan Quagmire